The advancement of ovarian rejuvenation offers hope for renewed fertility to women faced with the heartbreaking realities of advanced maternal age, low oocyte (egg) reserves, or either naturally occurring or premature menopause.
What Is Ovarian Rejuvenation?
The reproductive science community has long understood that the finite supply of eggs every woman is born bearing in her ovaries gradually decreases in quantity and quality over the course of her life. A team of Harvard University researchers changed the way physicians viewed that matter of course by observing mice that appeared to develop mature eggs from ovarian stem cells. Introducing isolated growth factor-bearing platelets directly into the ovaries might trigger a resurgence in oocyte production.
How Can Ovarian Rejuvenation Treatment Help Infertility
Harvard researchers have demonstrated the transformation of ovarian stem cells into mature oocytes in mice, suggesting the possibility that similar cellular bodies shown to be present in human ovaries may be able to transform similarly into healthy eggs. Once activated by growth factors after the body is alerted to an internal or external injury, stem cells can morph into any type of cell in the human body. You may have actually previously seen these miraculous substances at work without realizing it. That thick yellow substance that forms over a cut as it heels? That is a combination of clotting blood, white blood cells, platelets and growth factors working to defend against infection, stop bleeding, and gradually form new skin, blood vessels, nerves and connective tissue. It’s a natural process clinicians have harnessed for years to accelerate healing of injuries from sports-related damage to skin grafts applied to burn patients and cardiac-surgery incisions.
What Are Growth Factors?
Physicians have been employing growth factors to promote fast, effective healing for years. Sports medicine has long recognized their value to helping athletes heal at accelerated rates from injuries and surgery. They have also improved successful integration of surgical bone grafts and non-surgical skin grafts in burn victims. In fact, you have probably seen them at work yourself without even realizing it.
Think about the last external injury you suffered – something like a scraped knee or cut. Eventually, your wound developed a yellowish layer as it healed. That was a combination of clotted blood, white blood cells, platelets, and growth factors at work stopping pleading, preventing infection, and regenerating connective tissue, skin, blood vessels, and nerves.
When your body is injured, it dispatches substances known as “growth factors” to provide aid. Produced naturally by platelets and white blood cells, growth factors activate the body’s stem cells to repair tissue, and induce regrowth of connective tissue and blood vessels. Physicians have been utilizing growth factors to treat a range of soft or connective tissue injuries for years, since injecting platelet-rich plasma (PRP) from patients’ own bodies carries no risk of transmitting foreign diseases and infections. Additionally, there is no foreign blood products or man-made chemicals used in the process since it’s the patient’s own platelet rich plasma that is used.
How Is Ovarian Rejuvenation Procedure Performed?
The procedure can be performed anytime on women with or without periods.
Ovarian rejuvenation takes place following a two-step process. First, we will isolate your PRP by subjecting a tube of blood to centrifugation in order to separate white cells and platelets.
After a patient’s own blood is drawn, Ovarian Rejuvenation involves injecting a patient’s ovaries with her own platelet-rich plasma (PRP), infusing these oocyte-production centers with proteins rich in growth factors and stem-cell chemoattractants. It can be performed at any time on a woman who has stopped getting periods.
This stage takes under an hour. In the next and final stage, you will spend about 10 minutes under an intravenously administered anesthetic while we non-surgically inject a small amount of PRP directly into your ovaries, a procedure guided by transvaginal ultrasound. Afterward, you will sleep around one hour before being discharged to return home.
Due to the nature of the anesthetic used, we ask that patients not drink or eat anything for at least eight hours before undergoing This is a simple, common procedure used during IVF under IV sedation by an anesthesiologist. There is minimal complications since this is similar to egg retrieval that has been common practice for years.
Are There Any Risks?
The procedure carries roughly the same risks associated with In Vitro Fertilization (IVF) egg-retrieval: post-procedure pain, fever or internal bleeding that may require hospitalization in rare instances.
What Are The Benefits of PRP Fertility Treatment?
The greatest possible benefit? A chance to become pregnant using your own eggs. You assume no risk of bloodborne viral infections such as HIV or hepatitis, since you are strictly being injected with your own PRP with no synthetic materials involved at any time. As opposed to the laparoscopic procedure utilized during initial research, we opt for the same procedures employed to retrieve eggs for In Vitro Fertilization (IVF) in the name of a safer, less-invasive process with much shorter patient recovery time. In an ideal outcome, you will have a chance to become pregnant using your own naturally developed mature eggs without risking introduction of disease, infection or synthetic chemicals to your body.
Who Is An Ideal Candidate For Ovarian Rejuvenation?
Ovarian rejuvenation is ideal for menopausal or perimenopausal women with low egg reserves or Anti-Mullerian hormone levels or premature ovarian failure. After the rejuvenation procedure, we would measure progress by evaluating and measure AMH (anti-Mullerian hormone), FSH, LH and Estradiol levels along with the ovarian function for 1-3 months. Once we see AMH levels rise and FSH, LH and Estradiol levels diminish, this would be a positive sign that the ovarian rejuvenation is working. Please keep in mind that the effect of growth factors could take 3-6 months of observation since this type of tissue transformation takes time, and every person’s situation may be different.
For further information about the procedure and to discuss with a physician who will explain the process in detail, please contact NYFI at (212) 734-5555